Title: Green Synthesis of Gold, Iron and Selenium Nanoparticles Using Phytoconstituents: Preliminary Evaluation of Antioxidant and Biocompatibility Potential
Author: Abeer Jabra Shnoudeh, Lana Qadumii ,Malek Zihlif,Hamzeh J. Al-Ameer,Ruba Anwar Salou ,Abdulmutalleb Yousef Jaber and Islam Hamad , Published Year: 2022
Molecules, 27
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Abstract: This study aimed at fabricating gold (Au), iron (Fe) and selenium (Se) nanoparticles (NPs) using various natural plant extracts from the Fertile Crescent area and evaluating their potential application as antioxidant and biocompatible agents to be used in the pharmaceutical field, especially in drug delivery. The Au-NPs were synthesized using Ephedra alata and Pistacia lentiscus extracts, whereas the Fe-NPs and Se-NPs were synthesized using peel, fruit and seed extracts of Punica granatum. The phytofabricated NPs were characterized by the UV-visible spectroscopy, scanning electron microscope, Fourier transform infrared spectroscopy, X-ray diffraction (XRD) and energy-dispersive X-ray (EDS) spectroscopy. Scanning electron microscope technique showed that the synthesized NPs surface was spherical, and the particle size analysis confirmed a particle size of 50 nm. The crystalline nature of the NPs was confirmed by the XRD analysis. All synthesized NPs were found to be biocompatible in the fibroblast and human erythroleukemic cell lines. Se-NPs showed a dose-dependent antitumor activity as evidenced from the experimental results with breast cancer (MCF-7) cells. A dose-dependent, free-radical scavenging effect of the Au-NPs and Se-NPs was observed in the DPPH (2,2-Diphenyl-1-picrylhydrazyl) assay, with the highest effect recorded for Au-NPs

Keywords: gold-nanoparticles; iron-nanoparticles; selenium-nanoparticles; antioxidant potential; biocompatibility; green synthesis; Punica grantum; Ephedra; Pistachio leaves

2
Title: EVALUATION OF PHARMACY STUDENT AND COMMUNITY PHARMACIST KNOWLEDGE AND IMPACT ON DISEASE STATE MANAGEMENT OF PATIENTS WITH ASTHMA
Author: Qutaiba Ahmad Al Khames Aga, Mansour haddad, Yazan A. Bataineh, Abdel Naser Dakkah, Abeer Jabra Shnoudeh, Randa SH Mansour., Published Year: 2020
Systematic Rreviews in Pharmacy, 11
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Abstract: Objective: To evaluate the knowledge of pharmacy students and community pharmacists regarding etiology, symptoms, medications, prevention and history of asthma to correlate with the needs of training and years of experience and their impacts on patient. Methodology and design: This study was a cross sectional randomized study, involved pharmacy students in their last year from Philadelphia University-Amman, and different community pharmacists. Data was collected from 400 pharmacy students and 200 community pharmacists with different years of experience. Conclusion: Community pharmacists have good impact on patients with asthma; especially after having more than 6 years’ experience. Well-trained pharmacists with asthma knowledge of optimal device technique and medication maintenance in addition to good communication skills reduces the rate of hospital admission and improve quality of life for asthmatic patients

Keywords: Asthma, Knowledge, pharmacist, pharmacy students

3
Title: Chapter 6 - Influence of Drug Properties and Routes of Drug Administration on the Design of Controlled Release System, IN Dosage Form Design Considerations Volume i Advances in Pharmaceutical Product Development and Research 2018, Pages 179-223
Author: ArpnaIndurkhya, Mahendra Patel,Piyoosh Sharma, Sara Nidal Abed, Abeer Shnoudeh, Rahul Maheshwari, Pran KishoreDeb, Rakesh K.Tekade., Published Year: 2018
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Abstract: To achieve therapeutic drug concentration is not a major task, rather maintaining that concentration for the desired period is clinically more important and is a demanding area of drug delivery science. However, the design of controlled release formulations requires many factors to be considered such as drug delivery rate, delivery duration, physicochemical properties of the drug, nature of excipients, the route of administration, and the dosing interval etc. The objective of the chapter is to provide a complete understanding of several physicochemical properties of the drug that ultimately influence the performance of drug molecule. The chapter includes various aspects of designing controlled release formulations which includes rationale of design, drug properties (molecular weight, pH, pKa, etc.), pharmacokinetic aspects (absorption, distribution, etc.), pharmacodynamic aspects (dosing interval/frequency, patient condition, etc.), and route of drug administration (oral, transdermal, parenteral, etc.).

Keywords: Drug properties, controlled release, delivery system, routes of administration, patented CRS, pharmacokinetics pharmacodynamics, patient compliance

4
Title: Chapter 15 - Synthesis, Characterization, and Applications of Metal Nanoparticles, IN Biomaterials and Bionanotechnology Advances in Pharmaceutical Product Development and Research , Pages 527-612
Author: Abeer JabraShnoudeh, IslamHamad, Ruwaida W.Abdo, LanaQadumii, Abdulmutallab YousefJaber, Hiba SalimSurchi, Shahd Z.Alkelany1, Published Year: 2019
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Abstract: The most emerging branch of science during the last decade is nanoscience and nanotechnology. Metallic nanoparticles (NPs) have a great role in many scientific fields such as medicine, physics, mechanics, pharmaceutics, and others. In the last few years, scientists found great potential in metal NPs synthesis and applications and even used different spectroscopic or microscopic characterization methods. This book chapter covers the concept behind metal NPs, the advantages and role of metal NPs in pharmaceutical systems, and will focus on the synthetic methods for the production of different metal NPs by using physical, chemical, and biological approaches; allied characterization techniques including spectroscopic, microscopic, and physiochemical techniques; and the applications in medical technology of metal NPs including applications in drug, protein, peptide, and gene delivery; tissue engineering; enzymology; surface coating; biosensing devices; diagnostics and theranostics; in addition to many other applications, concluding with metal NPs’ future potential.

Keywords: Metal nanoparticlesgold NPssilver NPsiron NPscopper NPsselenium NPssulfur NPsplatinum NPsbimetallic NPs synthesis approachesnanoparticles characterizationnanoparticles applications

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Title: A novel compound JPM8: in vivo penile activity promotion in rats, effect on the relaxation and cGMP/cAMP accumulation in isolated rabbit corpora cavernosa
Author: T S El-Thaher, S Khatib, M Saleem, A Shnoudeh A A Badwan, Published Year: 2002
International Journal of Impotence Research, 14
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Abstract: JPM8 is a novel sildenafil-like PDE5 inhibitor. Its efficacy was tested in vivo by the oral administration of drugs to a rat model and recording penile activity changes. Effect on the relaxation of the rabbit cavernosa was tested in vitro using an organ bath were drugs are added to the tissue media and relaxation was recorded using a transducer connected to a chart recorder. The accumulation of cGMP and cAMP was measured by incubation of cavernosa strips and then extracting the produced cGMP and cAMP in the incubation mixture, then quantitating it using ELISA. JPM8 showed increased and promoted sexual and penile activity in rats in a similar but slightly higher trend than the positive control sildenafil. JPM8 was more efficient in relaxing the rabbit corpora cavernosa than sildenafil. The cGMP and cAMP accumulation showed a similar trend for both drugs. We concluded that JPM8 was very effective in promoting sexual activity in rats, relaxing the corpora cavernosa and promoting cGMP accumulation in rabbits.

Keywords: Phosphodiesterase 5, JPM8, cAMP, cGMP