QUESTIONS
- Calculate the plasma drug concentration after time 3 hours upon giving a dose of 4 mg/kg by a single IV bolus injection to a male who weighed 80 kg, the drug follows the pharmacokinetics of a one compartment model and has an elimination half life of 2 hrs, the apparent volume of distribution is 0.25 L/kg, is:
- What percent of the dose is remaining in the body at 5 hours if a 300 mg single dose of drug X was administered for a 22 years old male by IV bolus injection, the drug has an elimination t 1/2 of 2 hr and follows first-order kinetics,?
- Upon the administration of an IV bolus dose of drug X, the initial plasma drug concentration was 25.4 mg/mL, 7 hours later, the concentration was 10.1 mg/mL. Predict the plasma drug concentration at 19 hours. The drug follows a first-order and one-compartment kinetics.
- A single dose of 5g IV bolus of drug X was administered to 35 years old male, the drug has an initial rate of elimination was 116 mg/hr-1 and apparent volume of distribution is 32 L , the clearance would be:
- If the Initial plasma concentration of the drug is 10mg/ml while after 16 hours plasma drug concentration became 2.5 mg/ml . what is the half-life of this drug?
- A 400 mg dose of a drug was administered as an intravenous bolus injection. The drug has the following pharmacokinetic parameters: k = 0.2 h−1 and VD = 10L, Assuming the drug will be below MEC when levels decline to less than 5mg/L, when should you administer the next dose?
- How many half-lives (t1/2) would it take for 98.4% of a drug to be eliminated? Assume first-order kinetics.