Research Title: HPLC method development/validation and skin diffusion study of caffeine, methyl paraben and butyl paraben as skin –diffusing model drugs

Author: Randa Shehda Mansour, Published Year: 2021

Plos One, doi.org/10.1371/jour

Faculty: Pharmacy

Abstract: The focus of this research was to develop and validate a suitable HPLC method, which allows simultaneous determination of three proposed skin model penetrants to investigate the percutaneous diffusion behavior of their combination: caffeine, methyl paraben and butyl paraben. These penetrants were selected because they represent a wide range of lipophilicities. This model highlights the effect of combining penetrants of different molecular properties on their diffusion behavior through skin. The proposed method employed a gradient system that was systematically optimized for separation and quantification of the penetrants. The effect of the stationary phase (C18, C4 and cyano (CN)) was assessed with CN proven to be superior in terms of peak shape, retentivity and dynamic linear range. Significant differences in retention time, peak broadening, and quantifiability between different stationary phases could be demonstrated. The method was validated as per ICH guidelines Q2 (R1) with a satisfactory outcome. The method was successfully applied for real diffusion experiments, and revealed notable differences between the individual penetrants and their ternary mixture on transdermal permeation. The method could potentially be extended to determine these analytes in other related skin permeation investigations.

Keywords: HPLC, simultaneous; caffeine; parabens; in-vitro diffusion, stratum corneum

Research Title: Effect of Olea europaeaL. and Juglans regiaL. Extracts on Human Cancer Cell Line Viability with Studying ofHypoglycemic and Antiglycation Properties

Author: Raida W. Khalil, Published Year: 2021

Journal of Pharmaceutical Research International, 33

Faculty: Science

Abstract: here is an urgent and continuous need to discover new sources of medicinal plants to obtain useful compounds with health properties. So the purpose of this study was to investigate activity of OleaeuropaeaL and Juglans regia leaves extract on Hela cell line viability, antidiabetic and Antiglycation. The aqueous extracts were obtained from leaves. Alloxan 180 mg /kg body was used to induce diabetes. Mice with blood glucose level of ≥200 mg/dl were considered as diabetic and were received 10 mg/kg of body weight of Extracts. For Antiglycation, SDS-PAGE (sodium dodecyl sulphate–polyacrylamidegel electrophoresis) were prepared for the appearance of high molecular weight products. Hela cell line were cultured in RPMI-1640 medium for MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay analysis. The results showed that the mean of glucose levels decreasing in mice that treated with 10 mg/Kg extracts of O. europaeaand J. regia. Also SDS-PAGE showed that extracts of J. regiawere better than of O. europaea in inhibition of glycation induced protein cross-linking at all studied concentrations. MTT assay showed that the Cytotoxicity was increased with increasing the doses of extract and the cytotoxic effects of J.regiaextract were higher than O.europaeaat all concentrations. This study showed promising results.

Keywords: Olea europaea L; Juglans regia L; hypoglycemic; antiglycation;Hela cell line; MTT

Research Title: اعادة تأصيل معمارالبيت العربيفي ضوء الحضارة المعاصرة (دراسة حالة على بيوت جبل عمان القديمة - شارع الرينبو )

Author: Mohammad Mahmoud Ababnah, Published Year: 2020

المؤتمر الدوليا لثاني عشرللغات والآداب والدراسات الثقافية , تركيا - جامعة غازي عنتابوجامعة عثمان باشا

Faculty: Architecture and Design

Abstract: تعرضت عمارتنا التقليدية الى العديد من التشوهات في عناصرها المعمارية ما أدى الى تخبط هويتها المعمارية وضياعها ، فظهرت أشكال الأبنية الغريبة وغير المألوفة كتقليد لعمارة الغرب ، ويأتي ذلك بسبب القطيعة طويلة الأمد بين ثقافتنا وتاريخنا الحضري ما فسح المجال للعديد من الأصوليين المعماريين لبذل الجهد نحو الحفاظ على ما تبقى منها من مبان قديمة في المدن التقليدية والنسيج المعماري في عالمنا العربي . وتسببت قطيعة التراث المعماري في ضياع التراث ورفضه من قبل الأجيال الحديثة ، كما وتسببت العولمة أو ما يعرف بالانفتاح على ثقافات عديدة غيرت شكل ثقافتنا العربية الأصيلة التي عبثت في جوهرها ؛ فظهرت التصاميم الغريبة التي شوهت معمار المدينة العربية وتصاميمها التقليدية وجردتها من هويتها . يعد العامل الإنساني المقياس المشترك بين المعاصرة والأصالة ، فإذا استطاع المصمم الحفاظ على هذا المقياس فإن التأخي بينهما ممكن ، ويتجلى المقياس الانساني في القيم الروحية والقومية والمادية في العمارة المعاصرة (1) . فالمعاصرة لا يقصد بها الحداثة ولا تعد انتهاكاً للهوية التقليدية . علماً بأن المدن العربية وبيوتها القديمة تتجلى بالأصالة المعمارية التي تشير الى أن وجود المقوم في الشيء ووجوده في العمارة ضروري ، فهي نتاج بشري أصيل مقوم في تأصيلها وتكوينها عبر الزمن . ان العودة الى عمارتنا التقليدية المتواجدة في مدننا العربية وقرانا والتي تفيض بالأصالة والتراث تحتاج من المعماريين والمصممين العرب والأردنيين بشكل خاص الى تقوية أصر العلاقة تكاثف جهودهم فيما بينهم بالإضافة الى دور الأكاديميين في زيادة الوعي نحو تراثنا وعمارتنا الأصيلة وكيفية الحفاظ عليها . (1) عفيف ، بهنسي ، ما بعد الحداثة والتراث في العمارة العربية الإسلامية (عالم الفكر ) ، ج27 ، عدد 2، 1998، أكتوبر تعد عمّان من المدن العربية القديمة التي يزيد عمرها عن تسعة آلاف عام . ووضعت العديد من الحضارات بصمتها على هذه المدينة العريقة حيث بدأت بالحيثيين والهيكسوس وتلاهم العمونيون والإغريق والرومان والحضارة الإسلامية بمختلف فتراتها ، فآثارها بقيت شاهداً على هذه الحضارات المتعاقبة . وتأثرت العمارة التقليدية للبيوت والمباني المعمارية بالحضارات السابقة التي تواجدت على هذه الأرض وأثرتها بالعناصر الزخرفية والمعمارية لتزيد من جمالية ورونق البيت العربي الأصيل في مدينة عمّان ؛ إلا أن المدينة تعرضت وأبنيتها التراثية الأصيلة للعديد من التشويه والدمار ، ما أدى الى ضياع هويتها. ولقد حاول العديد من المصممين والمعماريين الأردنيين الحفاظ على ما تبقّى من تراثنا المعماري وتناولوا الموضوع من جهات مختلفة مما جعل بعضهم بالتعامل معه على أنه أمر شائك . وتسعى هذه الدراسة الى فهم كيفية التعامل مع ما بقي من تراثنا المعماري في مدينة عمّان والمحافظة عليها وزيادة الوعي بالموروث المعماري وأهميته خاصة في البيوت القديمة بجبل عمّان في شارع الرينبو هناك وإعادة تأصيلها وتوثيقها في ظل التصميم المعاصر في المدينة ، والوقوف على أهم عناصرها المعمارية والزخرفية ذات القيمة التاريخية وتحليلها والإستفادة منها في تصميم البيوت المعاصرة وذلك للوصول لمدينة معاصرة ذات عناصر معمارية أصيلة تعبّر عن هوية المدينة العربية وعراقتها وتؤكد على قيمها الإجتماعية . Our traditional architecture has been subjected to many distortions in its architectural elements, which led to the floundering and loss of its architectural identity, so unfamiliar and uncommon structures emerged as an imitation of Western architecture. This results in a long-standing break between our culture and our urban history. This put a foundation to encourage many architectural fundamentalists to make an effort to preserve what remains of it are heritage buildings in traditional cities and its architectural fabric in our Arab world. The estrangement of the architectural heritage that has led to rejection by modern generations. On the other hand, globalization or what is known as openness to many cultures changed the form of our authenticity of the Arab culture, which tampered with the Arab architecture essence and identity. The human factor is the common standard between contemporary and authenticity. If the designer is able to maintain this standard, then the delay between them is possible, and the human scale is reflected in the spiritual, national and material values in contemporary architecture (1). Contemporary is not intended for modernity and is not a violation of traditional identity. Note that Arab cities and their ancient homes are reflected in the architectural originality that indicates that the existence of the ingredient in the thing and its presence in the architecture is necessary, as it is an authentic human product that is rooted in its formation and composition over time. Returning to our traditional architecture found in our Arab cities and villages that overflow with originality and heritage requires Arab and Jordanian architects and designers, in particular, to strengthen the relationship’s insistence by intensifying their efforts among them. In addition to the role of academics in raising awareness towards our heritage and our original architecture and how to preserve it. Amman is considered one of the oldest Arab cities, which is more than nine thousand years old. Many different civilizations have left their mark on this ancient city, where it began with the Hittites and Hexus, followed by the Ammonites, the Greeks, the Romans and the Islamic civilization in its various periods. The city still preserves the effects as a witness to these successive civilizations. The traditional architecture of houses and buildings was affected by previous civilizations that existed on this city, which riched them with decorative and architectural elements to increase the aesthetic and elegance of the original Arab house in the city of Amman; Many Jordanian designers and architects have tried to preserve the remainder of our architectural heritage and dealt with this issue from various perspective, which made the impression that this is a complicated issue. This study seeks to understand how to deal with and maintain the remaining architectural heritage in the city of Amman and increase awareness of the architectural heritage and its importance, especially in the old houses on Jabal Amman on Rainbow Street. In order to re-rooting and documenting the architectural heritage in light of contemporary design in Amman, and to identify the most important architectural and decorative elements that hold historical value. To analyze and utilize it in the design of contemporary houses, to reach a contemporary city with authentic architectural elements that express the identity of the Arab city and its heritage and emphasize its social values

Keywords: تأصيل -البيت العربي -الحضارة -المعاصرة

Research Title: الخطاب النسوي في الاتجاه المعماري لدى زها حديد

Author: Mohammad Mahmoud Ababnah, Published Year: 2020

Faculty: Architecture and Design

Abstract: يحمل الخطاب النسوي بشكله العام الكثير من الاشكاليات التي دفعت أشخاصاً كثراً للتوقف امامه طويلاً ، ويأتي ذلك بسبب الجهل الفاضح وعدم دراية العديد منهم بالموضوع وقيمته . يمكن تفسير الخطاب النسوي تفسيراً يعبر عن هوية المرأة نفسها باعتبارها هوية متمددة خلافا لهوية الرجل ، وكما تقول ( اريجاري ) بأن تقييد أو حبس المرأة يعتبر انكاراً واضحاً لإمكانية التغيير الدال سواء للمرأة او الرجل معا في اطار تكوينهما البيولوجي . ويتمثل الخطاب النسوي في جوانب شتى بالحياة منها الاجتماعية والسياسية والفلسفية والفنون والعمارة . بالإضافة الى التعرف على مفهوم الخطاب النسوي في العمارة والتصميم سنتناول أعمال المعمارية العراقية الراحلة زها حديد بالتحليل وذلك لرصد مدى تنوع الأساليب التعبيرية عن الخطاب النسوي في مختلف مجالاته . تجسدت مسيرة زها حديد كامرأة في مهنة يطغى عليها الطابع الذكوري وكعربية في زمن يعاني فيه المواطن العربي التهميش والإهمال في عالم عربي يعاني من التفكك والدمار المادي والمعنوي. تنتمي حديد الى جيل ما بعد الحداثة الناتج عن الثورة الصناعية والمعلوماتية الهائلة حيث ظهرت فيه الأشكال المعقدة والتي كانت تعتبر من المستحيلات في عصر ما قبل الحداثة . استطاعت زها حديد التعبير عن المرأة وخطابها النسوي عن طريق تحويل المتناقضات والنزاعات والتحديات المعمارية الى قوى صانعة ومنتجة خلاقة من خلال الفكر التفكيكي التحليلي ، لإعادة تعريف المفاهيم وتشكيل منظور جديد مبنى على التغيير والاختلاف . في ظل الواقع الذكوري والظلم المجتمعي في المجال المعماري القائم على أسس الهندسة الإقليدية ( التقليدية) قامت زها حديد باجتراح منهج هندسي حداثي يقوم على استخدام المنحنيات المجردة بالعمارة حتى اطلق عليها لقب – ملكة المنحنيات – وتعتبر هذه هي طريقة زها حديد للتعبير عن خطابها النسوي وقدرتها كامرأة على مواجهة الصعاب ، واستطاعت أن تخلد اسمها كإحدى أفضل وأقوى المعماريين بالعالم . تسعى هذه الدراسة الى التعريف بالنسوية و بالخطاب النسوي من السياق المعماري لامرأة جسدت هنا الخطاب النسوي في اتجاهها المعماري للوصول للهدف النهائي وهو القضاء على جميع أشكال القهر الاجتماعي التي تتعرض لها المرأة واعطاءها المساحة الكافية لتوسع المشاركة والنهوض بالمجتمع .

Keywords: خطاب-نسوي-معمار

Research Title: Survey study: COVID-19 symptoms and lifestyle

Author: Raida W. Khalil, Published Year: 2021

world journal biology pharmacy and health science, 5

Faculty: Science

Abstract: In the middle of 2020 coronavirus had becoming spread around the world with a high number of people infected with covid-19, which makes covid-19 international pandemic that leads the governments around the world to decided strict roles to prevent the spreading of the virus, like wearing masks, social distance, e-learning and curfew. Because SARS-Cov2 is a novel virus, research groups around the world are making an effort to study the genetic material and structure of this virus and to find suitable treatment and vaccine. Also, they are trying to analyze the impact on the people who are infected with covid-19 especially after recovering. This preliminary study is trying to analyze the survey data collected from patients in the Middle East especially Jordan and Iraq, to find out how much lifestyle could affect the long-lasting symptoms caused by covid-19. According to the data, there is a strong relationship between lifestyle and long-lasting symptoms of covid-19 especially physical exercise, taking supplements and drink caffeine frequently. Recommend to get more worldwide study about the impact of lifestyle on the long-lasting symptoms of covid-19.

Keywords: COVID19; Long Lasting Symptoms; Lifestyle

Research Title: Nanocarriers in novel drug delivery system

Author: Mohammad Bayan, Published Year: 2021

Faculty: Pharmacy

Abstract: Recently, nanomedicines have been advanced and turned into an innovative approach for the diagnosis and treatment of several diseases. In particular, the medication is being delivered to the site of action through nanoparticles wherein these transporters are significant for effective treatment or management of diseases. The diversified nanocarriers support the targeted biomolecular interaction of drugs and can reduce various side effects thereby enabling the treatment more effectively. In this chapter, we depict the utilization of efficient nano-sized carriers in nanomedicine and nanotechnology in the treatment and diagnosis, respectively. Additionally, we discuss the targeted delivery of nanodrugs in a broader context through the availability of different nanocarriers. We also give a brief outlook on various nanomedicines developed utilizing distinctive and novel nanocarriers.

Keywords: Nanocarriers, Nanoparticles, Cancer, Nanomedicine, Novel drug delivery system.

Research Title: Salivary Inflammatory Mediators in Cancer Diagnosis

Author: Mohammad Bayan, Published Year: 2021

Sumerianz Journal of Medical and Healthcare, 4

Faculty: Pharmacy

Abstract: Cancer is the second leading cause of death worldwide; it can be successfully treated in the early stages. Screening for cancer should be performed in safe, accurate, cost-effective, and non-invasive techniques and therefore achieved the patient convenience. The salivary diagnosis could be a promising era in oncological fields, which have some correlations with serum biomarkers in certain cancers. In this paper, we reviewed some of the salivary biomarkers in detecting different cancers and their origins [genomics, epigenomics, transcriptomics, metabolomics, proteomics, and microbiota].

Keywords: Cancer screening; Salivary diagnosis; Salivaomics; Inflammatory biomarker.

Research Title: the Relationship Between the Return on Equity (ROE) and the Capital Structure of the Jordanian Public Shareholding Industrial Companies

Author: Jafer Maroof Al Sawalhah, Published Year: 2021

Academy of Accounting and Financial Studies Journal , Volume 25, Issue 1,

Faculty: Business

Abstract: This study aims at verifying the impact of the capital structure on the profitability in Jordanian industrial joint-stock firms, and how these companies managed their capitals through the period from 2006 to 2015. The methodology of this study relied on the descriptive approach to analyze and classify the available data using the multi regression analysis. The sample of the study included the Dar Al Dawa Development and Investment Company, and the Hayat Pharmaceutical Industries Company. The results of this study show that there are statistically significant effects at the significance level ( 0.05. = α ≤ 0.0 ) of the capital structure (debt) on the return on equity (ROE) in the Jordanian industrial shareholding companies. Descriptive statistics indicate that the financial leverage (FL) constitutes about 51% of the capital structure in the aforementioned companies, with the short-term financial leverage being the largest component of the financial leverage (FL). It is worth noting that the leverage ratio was almost constant during the study period (the standard deviation ratio was 0,113). As shown by the study results, the rate of interpretation of the independent variables on the dependent variable was 85% (Adjusted R2). It has been also noticed that the relationship between the capital structure ) indebtedness ( and the profitability (ROE) is positive, i.e. there is a statistical significance of financial leverage (FL) on the profitability index in the studied companies. Likewise, there is a statistically significant effect of other independent variables (except for the asset turnover ratio) on the profitability index.

Keywords: Capital Structure, Profitability, Multiple Linear Regressions, Financial Ratios.

Research Title: The Effect of Board of Directors and CEO on Audit Quality: Evidence from Listed Manufacturing Firms in Jordan

Author: Jafer Maroof Al Sawalhah, Published Year: 2021

The Journal of Asian Finance, Economics and Business, Volume 8 Issue 2

Faculty: Business

Abstract: his study aims to examine (1) the association between the chief executive officer tenure and audit quality, (2) the relationship between chief executive officer duality and audit quality, (3) the association between board independence and audit quality, (4) the relationship between board size and audit quality, and (5) the role of controlling variables (client size, leverage debt, and business complexity) in controlling these relationships. The research sample includes 325 financial reports from manufacturing firms listed in Amman Stock exchange over the 2014-2018 period. The study relationships are tested by using logistic regression. The results revealed a negative relationship, but not significant between CEO tenure and independent directors with audit quality. In addition, the results showed there is a negative effect of CEO duality on audit quality; also the results revealed that there is a statistically significant effect on the board of directors (board size) on the AQ. In general, the coefficient estimates of controlling variables show that client size and leverage debt positively affect audit quality, and on the contrary, business complexity has an insignificant positive relationship with audit quality. The summary of the study findings play an active role to external auditor opinion on business practice in towered the corporate governance system.

Keywords: Audit Quality; Corporate Governance; Chief Executive Officer Tenure; Chief Executive Officer Duality; Board Independence; Board Size

Research Title: Knowledge dimension in investment of the human capital as perceived by staff working in Jordanian insurance companies

Author: Jafer Maroof Al Sawalhah, Published Year: 2020

Journal of Public Affairs, e2251

Faculty: Business

Abstract: The main objective of this research is to address knowledge dimension of human capital in insurance sector in Jordan. There is an urgent need for studies on human capital, including intellectual capital (IC). After a thorough review of the research literature, the researchers were able to develop a questionnaire to apply to insurance companies in Jordan. In this study, the sample of 30 companies has been randomly selected from Amman, Zarqa, and Irbid in the insurance sector in Jordan. Means, SD, ANOVA analysis, and “Tukey Test” were used. Multiple regression was extracted for the first hypothesis, for subhypothesis simple regression is used. For the correlation indicator, we used Multicollinearity, finally Stepwise Regression was used. The values of the calculated t‐ratios for the staff position show that the nonsupervisory staff feel more than the supervisory staff in Staff Recruitment and Job Environment variables. And the supervisory staff feel more than the nonsupervisory staff in Staff Development. The values of the calculated t‐ratios for the gender show that the male staff feel more than the female staff in Staff Recruitment and Job Environment variables. And the female staff feel more than the male staff in Staff Development. The values of the calculated F‐ratios for each of the factors affecting knowledge dimension of the investment in human capital high and it can be concluded that there is significant statistical evidence that differences between factors exist according to the staff Work Place in variables Staff Recruitment, Job Environment, and Staff Development. Result of the test showed that staff who's working in Irbid feel in Staff Recruitment variable more than staff who's working in Zarqa. And the staff who's working in Zarqa feel in Staff Development variable more than staff who's working in Amman.

Keywords: investment of the human capital