Research Title: Characterization of Insulin Mucoadhesive Buccal Films: Spectroscopic Analysis and In Vivo Evaluation

Author: Randa Shehda Mansour, Published Year: 2021

Symmetry, 13

Faculty: Pharmacy

Abstract: Insulin mucoadhesive buccal films (MBF) are a noninvasive insulin delivery system that offers an advantageous alternative route of administration to subcutaneous injection. One major concern in the formulation of insulin MBF is the preservation of an insulin secondary structure in the presence of the other film components. Buccal films were formulated using chitosan, glycerin, and L-arginine. The MBF-forming solutions (MBF-FS) and the films (MBF) were examined for their chemical and structural stability and for their in vivo activity. Enzyme-Linked Immunosorbent Assay (ELISA) of the insulin-loaded MBF showed that each individualized unit dose was at least loaded with 80% of the insulin theoretical dose. Results of Synchrotron Radiation Circular Dichroism (SRCD) measurements revealed that MBF-FS retained the -helices and –sheets conformations of insulin. Fourier transform infrared (FTIR)-microspectroscopy (FTIR-MS) examination of insulin MBF revealed the protective action of L-arginine on insulin structure by interacting with chitosan and minimizing the formation of an unordered structure and -strand. A blood glucose-lowering effect of insulin MBF was observed in comparison with subcutaneous (S.C) injection using a rat model. As a result; chitosan-based MBFs were formulated and characterized using SRCD and FTIR-MS techniques. Furthermore, the results of in vivo testing suggested the MBFs as a promising delivery system for insulin.

Keywords: insulin; chitosan; mucoadhesive; buccal films; synchrotron radiation circular dichroism;FTIR-microspectroscopy; in vivo

Research Title: Pharmaceutical Mini-Tablets Overview

Author: Mohammad Bayan, Published Year: 2021

Indian Journal of Forensic Medicine & Toxicology, 15

Faculty: Pharmacy

Abstract: Oral dosage forms are considered as the most preferred dosage forms to various age groups of patients. However, conventional solid dosage forms (tablets and capsules) have been associated with some issues; such fluctuation in the plasma drug concentration and swallowing difficulty for some patients. This advocates the need for the continuous development and improvement of tablets and capsule to enhance therapeutic efficacy and increase patient acceptance. Mini tablets technology has been developed to minimize these problems. It aims to facilitate oral administration with minimal swallowing difficulty (especially in pediatrics and geriatrics) and deliver a therapeutic agent, selectively and effectively, to be targeted in a certain position in the body. The most benefit of this technique is the ease of production with facilitated control of stability problems. The size and shape uniformity, with smooth surface area, make minitablets attractive to be incorporated with different medications for the efficient treatment of chronic diseases. This overview outlines properties, production requirements, formulation options and evaluation methods of mini tablets

Keywords: Mini Tablets, multiple unit dosage forms, compressed mini tablets.

Research Title: DRUG RELEASE CONTROL AND ENHANCEMENT USING CARRIERS WITH DIFFERENT CONCENTRATIONS OF CAPMUL® MCM C8

Author: Mohammad Bayan, Published Year: 2021

International Journal of Applied Pharmaceutics, 13

Faculty: Pharmacy

Abstract: Objective: The main aim of this study was to design a drug carrier capable to control and enhance the release of poorly water soluble drugs. Methods: Three polymeric formulations, based on poly (2-hydroxyethyl methacrylate) and loaded with different Capmul® MCM C8 concentrations (0, 10 and 20 % w/w), were prepared. Felodipine, which is a poorly soluble substance, was selected as a model drug. The effect of Capmul® MCM C8 on swelling behavior and in vitro release profile of the prepared polymer was investigated in PBS. Results: The swelling profiles of allformulationswere statistically similar, which indicated the non-significant effect of added Capmul® MCM C8 on polymer's swelling behavior. All formulations showed a delayed drug release. Formulation-F3, which is loaded with 20% w/wCapmul® MCM C8 displayed a significant higher release compared to the other formulations. Conclusion: Capmul® MCM products, which are widely used in food industries, can be used to improve the oral delivery of poorly soluble substances. The optimized formulation exhibited the ability to control and enhance the release of the model drug.

Keywords: Capmul® MCM C8, Drug delivery, Free radical polymerization, Bioavailability enhancement

Research Title: Relationship between Bank Credit and Economic Growth: Evidence from Jordan

Author: Izzeddien Naef Ananzeh, Published Year: 2016

International Journal of Financial Research, Vol. 7, No. 2

Faculty: Business

Abstract: Despite the growing literatures that examined the relationship between financial developments and growth of any economy, there is scarceness in the empirical studies that examine the influence of bank credit on economic performance or growth at secrotal level of any country. Therefore this study came to examine the relationship between bank credit and economic growth in Jordan at different sectors for the period that span from 1993 to 2014. We employ two different methodologies Vector Error Correction Model (VECM) and Granger Causality Test, The results report for a long run relationship could be inferred between Real GDP, and its Explanatory variables of Total Bank Credit (TBC); Bank Credit for Agriculture sector (CFA); Bank Credit for Industry sector (CFI); Bank Credit for Construction sector (CFC); Bank Credit for Tourism sector(CFT). So we can suggest that TBC, CFA, CFI, CFC, and CFT are in the long term relationship with the development of Jordanian economy. Granger causality test conclude for a causal relationship going from economic growth to bank credit at agriculture and construction sectors in Jordan economy. Also the results report bidirectional causality observed among economic development and bank credit to construction sector that is the most important sectors in this economy. Moreover, our results point out that the efficiency of the bank credit facilities in a major economic sectors has an important role in the Jordanian economic growth, and shows the needs to enhance the role of financial sector for different economic sectors by adopting more appropriate macroeconomic policies.

Keywords: : bank credit, economic growth, (VAR) model, Vector Error Correction Model (VECM)

Research Title: التعليم بوصلة التنمية المستدامة

Author: Amani Ghazi Jarrar, Published Year: 2021

Faculty: Arts

Abstract: يسعى كتاب (التعليم بوصلة التنمية المستدامة ) إلى تقديم رؤية مستقبلية من أجل إعادة هندسة التعليم لخدمة بناء المنظومة التربوية على أسس علمية تراعي القيم الإنسانية عند تخيل التعليم لإنتاج شباب حضاري قادر على التغيير الإيجابي المنشود لخدمة المجتمع الإنساني كافة . ولغايات تحقيق ذلك في عالمنا المعاصر، كان لا بد من البدء بعالمنا العربي الأكثر تراجعا في المجال التربوي التعليمي ، حيث تناول الكتاب أحد عشر فصلا . وخير ما يمكن البدء فيه عمليا وعلميا هو ما عرض في الفصل الأول من حيث مراجعة تاريخ التربية والتعليم في الوطن العربي باعتباره البدايات الواجب الوقوف عليها لتفحص الماضي من أجل نظرة نقدية حقيقية لا تقبل التجميل بل تحاكي الواقع بوضوح لتقييمه بشفافية . ويتناول الفصل الثاني فلسفة التربية والتعليم في القرن الحادي والعشرين باعتبارها الأساس في أي تغيير يجب أن يطاله الباحث الراغب في إعادة البناء للحصول على نتائج أفضل تتخلص من عقد ومشاكل الماضي ونقاط الضعف ،مما يتطلب منا تحليل شامل للمنظومة التربوية. ولأن المعلم أداة التغيير الرئيسية ،كان لابد من تخصيص الفصل الثالث لبحث الابداع وتنمية المعلم ، فلم يعد مقبولا اتباع أدوات وآليات تقليدية ،بل كانت ضرورة تبني استراتيجيات ابداعية من أجل التعليم الجيد . وقد تم اختيار الفلسفة كمحرك رئيسي للتعليم الجيد ،فقد تناول الفصل الرابع الفلسفة وتنمية التفكير . كما يبين الكتاب ان تعليم الفنون والموسيقى ضرورة وليست ترفا من أجل تنمية الحس الجمالي ،فتناول الفصل الخامس ذلك بشيء من التوضيح . ولأن الشباب هم فرسان التغيير ،ولأن نظرة المجتمع للمرأة تعتبر من أهم القضايا الواجب تغييرها في مجتمعات المعرفة ، فقد خصص الفصل السادس لهذه الغاية . أما الفصل السابع فقد خصص لبحث كيفية تطوير العقلية الريادية وأهمية إعادة التفكير في قطاع التعليم عموما ، حيث ضرورة الاهتمام بالتربية من أجل التنمية المستدامة بالشكل الأمثل المنشود،وهو مدار بحث الفصل الثامن . كما تناول الفصل التاسع أهمية بناء الانسان الاخلاقي ليتمكن من الانخراط في عالم اليوم باعتباره مواطنا عالميا . وقد عالج الفصل العاشر إصلاح وإثراء التعليم والمنظومة التربوية بالمجمل ، مما مهد بالتالي الى معالجة الفصل الحادي عشر من حيث إعادة تخيل التعليم في مجتمع المعرفة وفي زمن الأزمات ،فقد آن الأوان لإعادة هندسة التعليم من أجل التنمية المستدامة لتحقق نجاحات منشودة على مستوى الإنسانية . https://www.addustour.com/articles/1192242-«التعليم-بوصلة-التنمية-المستدامة»-كتاب-جديد-للدكتورة-أماني-غازي-جرار https://anbaalwatan.com/newsid=340392.htm https://www.petra.gov.jo/Include/InnerPage.jsp?ID=4553&lang=ar&name=culture_news

Keywords: التعليم ،التنمية المستدامة

Research Title: دور تفعيل استخدام تقنيات التواصل الاجتماعي على التعلم الفعال للشباب: الاردن كحالة دراسية

Author: Amani Ghazi Jarrar, Published Year: 2017

دار الأطروحة للنشر العلمي, 1

Faculty: Arts

Abstract: هدفت الدراسة إلى تقييم أثر استخدام وسائل التواصل االجتماعي الحديثة ودورها في التعلم الفعال للشباب ،وقد استخدم طلبة جامعة فيالدلفيا في االردن كحالة دراسية . وقد اعتمدت الدراسة منهجية الوصف التحليلي، من خالل تطبيق أداة الدراسة على عينة من الشباب الجامعي األردني-جامعة فيالدلفيا. وفي ضوء تحليل البيانات، أظهرت النتائج أنه توجد عالقة ذات داللة إحصائية بين استخدام وسائل التواصل االجتماعي ودورها في تعزيز العملية التعلمية التعليمية . وقد طبقت الدراسة على عينة من )022 )طالب من مختلف المستويات الجامعية والكليات األكاديمية في جامعة فيالدلفيا في العام الدراسي )0202-0202 . )وفي ضوء مناقشة البيانات المتعلقة بعينة الدراسة وتحليلها، خلصت الدراسة إلى أن استخدام وسائل التواصل الفعال يؤثر إيجابا لجعل التعلم اكثر فعالية ، وهي الفرضية التي تم التحقق من صحتها.

Keywords: تقنيات التواصل االجتماعي ، التعلم الفعال ، طالب جامعة فيالدلفيا ، الشباب الجامعي األردني.

Research Title: CULTURAL AND IDEOLOGICAL FACTORS AFFECTING DEVELOPMENT IN THE ARAB WORLD: JORDAN AS AN EXAMPLE

Author: Amani Ghazi Jarrar, Published Year: 2018

Faculty: Arts

Abstract: It is proven that cultural and ideological factors affected development in the Arab world. Jordan is taken in this research as an example. Ideological and cultural factors are affected by other overlapping factors, such as political, economic, or social interacting factors. The research applies the analytical method on the cultural and ideological patterns in light of the major problems the Arab world is facing nowadays. It aims at assessing the status and the process of cultural development in the Arab world in an attempt to comprehend the reality, trying to rethink the future of the Arab world through understanding the obstacles and problems facing the Arab mind. The research applies the analytical pattern to the structure of societies in the Arab world in general, including political, economic, social and cultural aspects as well. The researcher concluded by confirming the reference of all previous components to the ideological fundamentals, stating that the main component of the Arab layout of mindset and civilization, that affects the process of cultural development in the Arab world , is the assimilation of the political and even the religious ideological dimensions affecting the context of the Arab mind. https://www.universitypublications.net/hssr/0802/html/H8V218.xml

Keywords: Cultural development, Arab world, Political factors, Ideological context, Intellectual development, Jordan.

Research Title: Regulatory Impact Assessment Role in Developing Participatory Work between Civil Society Organizations and Jordanian Ministry of Political and Parliamentary Affairs

Author: Amani Ghazi Jarrar, Published Year: 2018

Journal of Politics and Law, 11

Faculty: Arts

Abstract: The study points out the role of regulatory assessment in developing participatory work in Jordan focusing on both civil society organizations and Ministry of Political & Parliamentary Affairs. Jordan, nowadays ,has a rapidly evolving policy and regulatory environment. The problem that is rooted in our societies and national institutions manifests in the absence or lack of coordination in order to achieve the desired results that are planned to reach, namely the efficiency and effectiveness of the institutional performance of all sectors, especially the development sectors. The study poses the questions dealing with empowering a decentralized RIA System in Jordan, mainly: Determining the policies to be achieved to solve the problem, identifying the problems to be treated, determining the appropriate option for policy enforcement, determining the type of legislation required, determining who is responsible for preparing these legislations, and identifying the necessary legal and administrative mechanisms required. The research used the descriptive analytical, methodology. The study proposes an institutional mechanism of the (RIA) in Jordan. https://ccsenet.org/journal/index.php/jpl/article/view/73802

Keywords: regulatory impact assessment (RIA), participatory work, civil society organizations, political and parliamentary affairs, Jordan

Research Title: Role of Youth Associations in National Education and Extremist Intellectual Behavior Tendency of Jordanian Youth

Author: Amani Ghazi Jarrar, Published Year: 2017

International Education Studies, 10

Faculty: Arts

Abstract: This study aimed at identifying the role of Jordanian youth associations in spreading the national education and its relation to the tendency towards extremist intellectual behavior among a sample of Jordanian university students. The study population consists of (504) undergraduate students in the Jordanian universities, namely: Jordan University, Yarmouk University, Philadelphia University, and Al-Ahliyya Amman University. They were chosen in a deliberate manner. And have participations in activities organized by students' affairs deans in their universities. The reliability and validity of the study tool were verified. The results of the study showed that the role of the Jordanian youth associations in spreading the national education came within the intermediate level. The results also showed no statistically significant differences in the role of the Jordanian youth associations in spreading the national education according to the gender variable and the place of residence. There was also a strong correlation between the level of national education and the tendency towards intellectual extremism among Jordanian university students. https://www.ccsenet.org/journal/index.php/ies/article/view/70895

Keywords: youth associations, national education, extremist intellectual behavior, University students, Jordan

Research Title: Undescribed phenylpropanoid and a dimeric sesquiterpenoid possessing a rare cyclobutane ring from Tinospora sinensis

Author: Manal Mohammad Alhusban, Published Year: 2020

Natural Product Research,

Faculty: Pharmacy

Abstract: A rare dimeric sesquiterpenoid (tinosposinoside, 1) and a phenylpropanoid (cordifolioside C, 2), two undescribed metabolites, were isolated from the methanolic extract of the stems of Tinospora sinensis together with thirteen known compounds. This is the second example of a sesquiterpene dimer where two monomers linked together through a cyclobutane ring, possibly generated through [2 + 2] cycloaddition. The structures of 1 and 2 were elucidated by NMR and mass techniques.

Keywords: Tinospora sinensis; Menispermaceae; isolation; NMR; tinosposinoside; cordifolioside C