Research Title: Recent advances in mesalamine colonic delivery systems

Author: Mohammad Bayan, Published Year: 2020

Future Journal of Pharmaceutical Sciences, 6

Faculty: Pharmacy

Abstract: Background: Increased attention has been focused on the continuous development and improvement of mesalamine colonic specific delivery systems, for the effective treatment of inflammatory bowel diseases; thus enhancing therapeutic efficacy and reducing potential side effects. Mesalamine is a class IV drug, according to the Biopharmaceutics Classification System, used usually to treat inflammation associated with colon related diseases such as Crohn’s disease and ulcerative colitis. Main text An ideal colon targeting system aims to deliver a therapeutic agent, selectively and effectively, to the colon. This system should ideally retain the drug release in the upper GI tract (stomach and small intestine); while trigger the drug release in the colon. Several approaches have been used to fabricate formulations to achieve a colon specific delivery of mesalamine such as; time dependent, pH responsive, enzymatic/microbial responsive and ultrasound mediated approaches. This overview outlines the recent advances in mesalamine-colon delivery approaches for the potential treatment of ulcerative colitis and Crohn’ disease. Conclusion: A combined pH-time dependent delivery system can improve mesalamine colonic drug delivery via employing carriers capable of retarding mesalamine release in the stomach and delivering it at predetermined time points after entering the intestine. The existence of specific enzymes, produced by various anaerobic bacteria present in the colon advocates the advantage of designing enzyme sensitive systems and combining it with pHtime dependent system to improve mesalamine colonic delivery. The use of ultrasound has shown promises to effectively treat inflammatory bowel diseases.

Keywords: Mesalamine, 5-amino salicylic acid, Mesalazine, Crohn’s disease, Ulcerative colitis

Research Title: Mind Maps of Clinical Nephrology

Author: Mohammad Bayan, Published Year: 2020

Faculty: Pharmacy

Abstract: A student who has entered the portals of colleges finds it difficult to understand the subjects taught to him. This book is written in a very simple and easy style. It is up-to-date and exhaustive in covering the core topics of nephrology. The first book of mind maps in clinical nephrology that covered the fundamentals of nephrology to gain a clear understanding, providing detailed, specific information on the principles of chemical processes within and relating to living organisms. This book aims to address new changes in a variety of clinical disturbances using diagramming tools, to generate, visualize the structure and classify ideas, and as an aid studying and organizing information, solving problems, making decisions and writing. We continue to welcome constructive comments from all students who use our book as part of their studies and academics who adopt the book to complement their teaching.

Keywords: Mind maps, Nephrology

Research Title: Nanomedicines in Tuberculosis: Diagnosis, Therapy and Nanodrug Delivery

Author: Mohammad Bayan, Published Year: 2020

Faculty: Pharmacy

Abstract: Nanoparticle-based delivery systems represent a promising nano medications to deliver a therapeutic agent, selectively and effectively, to a specific tissue or organ in the body; thus treating chronic diseases such as tuberculosis. The delivery of first-line and second-line antituberculosis drugs, using synthetic or natural polymeric carriers, has been extensively reported as a potential intermittent chemotherapy. In addition to the prolonged drug release, this delivery system can enhance the therapeutic efficacy, reduce dosing frequency and side effects, and increase the possibility of selecting different routes of chemotherapy and targeting the site of infection. The choice of carrier, system stability, toxicity and production capacity are the main considerations during the development of such system. Regardless of the obstacles, the nano drug delivery have systems shown a promising effectiveness in treating TB.

Keywords: Nanomedicines, Nanodrug delivery, Chemotherapy, Tuberculosis

Research Title: In Vitro Release of Na-Fluorescein from pH Responsive Microgels

Author: Mohammad Bayan, Published Year: 2016

10TH WORLD MEETING on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, SECC, Glasgow

Faculty: Pharmacy

Abstract: In Vitro Release of Na-Fluorescein from pH Responsive Microgels

Keywords: Microgels, Microfluidics

Research Title: Preparation of Monodisperse Smart Microgels Using Microfluidic Technology

Author: Mohammad Bayan, Published Year: 2016

the 38th All Ireland Schools of Pharmacy Research Conference, Royal College of Surgeons in Ireland, Dublin

Faculty: Pharmacy

Abstract: Preparation of Monodisperse Smart Microgels Using Microfluidic Technology

Keywords: Microfluidic Technology, Microgels

Research Title: Preparation of pH-Responsive Microgels Using Microfluidic Technology

Author: Mohammad Bayan, Published Year: 2015

The 6th APS International PharmSci 2015, East Midlands Conference Centre, Nottingham, UK

Faculty: Pharmacy

Abstract: Preparation of pH-Responsive Microgels Using Microfluidic Technology

Keywords: Microgels

Research Title: Drying Using Supercritical Fluid Technology as a Potential Method for Preparation of Chitosan Aerogel Microparticles

Author: Mohammad Bayan, Published Year: 2015

AAPS PharmSciTech, 16

Faculty: Pharmacy

Abstract: Supercritical fluid technology offers several advantages in preparation of microparticles. These include uniformity in particle size, morphology, and drug distribution without degradation of the product. One of the recent advantages is preparation of porous aerogel carrier with proper aerodynamic properties. In this study, we aimed to prepare chitosan aerogel microparticles using supercritical fluid (SCF) technology and compare that with microparticles produced by freeze drying (FD). Loading the prepared carriers with a model drug (salbutamol) was also performed. Comparisons of the particle properties and physicochemical characterizations were undertaken by evaluating particle size, density, specific surface area, and porosity. In vitro drug release studies were also investigated. The effect of many variables, such as molecular weight of chitosan oligomers, concentrations of chitosan, and concentrations of tripolyphosphate on the release, were also investigated. Chitosan aerogels were efficiently produced by SCF technology with an average particle size of 10 μm with a tapped density values around 0.12 g/mL, specific surface area (73–103) m2/g, and porosity (0.20–0.29) cc/g. Whereas, microparticles produced by FD method were characterized as cryogels with larger particle size (64 microns) with clear cracking at the surface. Sustained release profile was achieved for all prepared microparticles of salbutamol produced by the aforementioned methods as compared with pure drug. The results also demonstrates that chitosan molecular weight, polymer concentration, and tripolyphosphate concentration affected the release profile of salbutamol from the prepared microparticles. In conclusion, SCF technology was able to produce chitosan aerogel microparticles loaded with salbutamol that could be suitable for pulmonary drug delivery system.

Keywords: aerodynamic; aerogels; chitosan; salbutamol; supercritical fluid technology

Research Title: Green Synthesis, Experimental and Theoretical Studies to Discover Novel Binders of Exosomal Tetraspanin CD81 Protein

Author: Balakumar Chandrasekarn, Published Year: 2020

ACS Omega,

Faculty: Pharmacy

Abstract: A new class of benzothiazole-appended quinoline derivatives (6–8) was synthesized via one-pot TPGS micellar-mediated acid-catalyzed nucleophilic addition, followed by aerobic oxidative cyclization of 3-formylquinoline-2-one (2), 3-formylquinoline-2-thione (3), and 2-azidoquinoline-3-carbaldehyde (4) individually with 2-amino thiophenol (5). The structures of the prepared compounds were confirmed using suitable spectroscopic methods complemented with single-crystal X-ray diffraction analysis. Time-dependent density functional theory-based optimization of molecular structures, bond lengths, bond angles, HOMO–LUMO energy gaps, and molecular electrostatic potential maps was theoretically computed at the B3LYP/6-311++g(d) level. The molecular docking studies recommended that 6–8 bound to the active site cavity of CD81 effectively with the binding energies of −6.9, −6.3, and −6.5 kcal mol–1, respectively. Further, MD simulation studies of compound 6 suggested that the binding resulted in the stabilization of the CD81 molecule. Thus, all theoretical predictions associated with the experimental verifications motivated to discover novel approaches for cancer therapy.

Keywords: Vesicles,Free energy,Peptides and proteins,Molecules,Electrostatic potentia

Research Title: Association between Gasdermin A and Gasdermin B polymorphisms and allergic rhinitis amongst Jordanians

Author: Tawfiq Froukh, Published Year: 2020

Endocrine, Metabolic & Immune Disorders - Drug Targets , 10.2174/187153032066

Faculty: Science

Abstract: Introduction: Gasdermin A (GSDMA) and Gasdermin B (GSDMB) have been associated with childhood and to a lesser extent with adult asthma in many populations. In this study, investigate whether there is an association between GSDMA (rs7212938, T/G) and GSDMB (rs7216389, T/C) at locus 17q21.2 and risk of Allergic Rhinitis among Jordanians. Also we aimed to determine if there is an association between such polymorphisms and the IgE level. Methods: The study included 112 rhinitis patients and 111 Healthy controls. Gasdermin A (GSDMA) (rs7212938, T/G) and Gasdermin B (rs7216389, T/C) polymorphisms were genotyped using the PCR-RFLP method. Results: On the genotype level, three analysis models were applied namely co-dominant, dominant and recessive genotypes. GSDMB CC genotype was found to be significant protective effect against of allergic Rhinitis (< 0.05). cc genotype was also significantly associated with higher IGE level among the studied population. Conclusion: The GSDMB CC of homozygous minor genotype showed a protective effect against Allergic rhinitis. It also was found to be significantly associated with lower IGE level among the studied population. No association was found between GSDMA with the risk of allergic Rhinitis.

Keywords: Gasdermin A, Gasdermin B, polymorphisms, allergic rhinitis, Jordanians, IGE.

Research Title: Repairing of Circular Reinforced Concrete Columns Damaged By Heat Using Carbon Fiber Reinforced Polymers (CFRP) (Rope) Technique

Author: Ala Taleb Obaidat, Published Year: 2020

5th International Conference on Civil and Environmental Engineering for Sustainability IConCEES 2019, Johor, Malaysia

Faculty: Engineering and Technology

Abstract: This study investigated the behavior of repaired circular reinforced concrete RC columns exposed to temperature considering effect of spacing between CFRP ropes, number of layers of carbon fiber reinforced polimers CFRP and degree of temperature. Six circular RC specimens divided into two groups with diameter of 185 mm and length of 800 mm were tested. First and second groups consisted of three RC columns exposed to temperature degree of 400°C and 600°C, respectively. In each group, the first column used as control specimen, the second and third RC columns were repaired using one layer and two layers of CFRP ropes, respectively. The results showed that the repaired RC columns damaged by heated up to (400°C and 600℃) with one layer of spacing 100 mm and two layers of spacing 200 mm exhibited load capacity about (140% and 188%) and (123% and 164%), respectively as control specimen. Hence, one layer of CFRP rope at spacing of 100 mm was more effective than two layers at spacing of 200 mm. In addition, as the exposure temperature of fire increases, the regained capacity of the repaired column increase.

Keywords: FRP rope, Heat Damaged, Circular column