Research Title: The Role of Environmental Design in Preserving the Archaeological Artifacts and its Sustainability “As-Salt Archaeological Museum -Toukan House - as a Case Study”

Author: Saif Mohammad Obeidat, Published Year: 2023

Jordan Journal or Fine Arts,

Faculty: Architecture and Design

Abstract: This research studies the importance of environmental development and its elements in achieving a safe environment to preserve the preservation of archaeological holdings in heritage buildings. The problem of the research lies in the lack of previous studies specialized in providing means of protection for heritage collectibles in the internal vacuum showing the role of environmental design in achieving protection for these holdings. The main question comes to clarity the role of environmental design in protecting and upright holding in the internal branches. The research is an important step to study the role of the environmental design in preserving heritage building and their replicas and provide reform and guidance to deal with the interior heritage branches is a sustainable manner. The methodology used in this research is descriptive analytical, in addition to an exploratory field visit, during which it was determined whether the internal void had an impact on the holdings inside it. The results of this research confirm that: (1) Environmental design has an important and effective role in achieving a design system based on functional and aesthetic diversity, (2) It has real importance in providing a safe and sustainable environment for archaeological holdings, (3) and has a significant impact on raising awareness among community members of the importance of preserving heritage collectibles, (4) also has a successful role in raising the levels of positive behavior among individuals, and finally (5) has a role in increasing the performance, efficiency and services of buildings.

Keywords: Environmental design, Heritage collections, Sustainability, Toukan House, As-Salt.

Research Title: Target protein degradation by protacs: A budding cancer treatment strategy

Author: Mohammad Bayan, Published Year: 2023

Pharmacology and Therapeutics, 250

Faculty: Pharmacy

Abstract: Cancer is one of the most common causes of death. So, its lethal effect increases with time. Near about hundreds of cancers are known in humans. Cancer treatment is done to cure or prolonged remission, and shrinkage of the tumor. Cytotoxic agents, biological agents/targeted drugs, hormonal drugs, surgery, radiotherapy/proton therapy, chemotherapy, immunotherapy, and gene therapy are currently used in the treatment of cancer but their cost is high and cause various side effects. Seeing this, some new targeted strategies such as PROTACs are the need of the time. Proteolysis targeting chimera (PROTAC) has become one of the most discussed topics regarding cancer treatment. Few of the PROTAC molecules are in the trial phases. PROTACs have many advantages over other strategies such as modularity, compatibility, sub-stoichiometric activity, acting on undruggable targets, molecular design, and acts on intracellular targets, selectivity and specificity can be recruited for any cancer, versatility, and others. PROTACs are having some unclear questions on their pharmacokinetics, heavy-molecular weight, etc. PROTACs are anticipated to bring about a conversion in current healthcare and will emerge as booming treatments. In this review article we summarize PROTACs, their mechanism of action, uses, advantages, disadvantages, challenges, and future aspects for the successful development of potent PROTACs as a drug strategy.

Keywords: PROTACs, Cancer, E3 Ligases, Protein Degradation, Ubiquitination.

Research Title: The Moderating Role of Liquidity in the Relationship between the Expenditures and Financial Performance of SMEs: Evidence from Jordan

Author: Fahd Mohammed Saleh Al-Duais, Published Year: 2023

Economies, 11(4)

Faculty: Business

Abstract: The current paper aims to investigate the moderating role of liquidity in the relationship between accounting and advertising expenditures and the financial performance of small and medium enterprises (SMEs) in Jordan. Furthermore, the present paper highlights the importance of managing expenditures and improving financial performance. Since the performance of Jordanian SMEs is extremely critical, furthermore, the present paper explores the possibility of empowering these businesses in order to achieve profitability. This paper is based on descriptive statistics, regression, and correlation analysis in order to analyze the data, collecting secondary data from 200 SMEs. The results demonstrate that accounting expenditures are key factors for financial performance, especially in SMEs. Moreover, SMEs are more sensitive to liquidity challenges, which significantly impact their short-term expenditure and consequently influence their financial performance. It is evident that accounting expenditures moderated by liquidity have a positive effect on the financial performance of SMEs. However, our findings indicate a negative effect regarding the relationship between advertising expenditures and financial performance. According to the results of this study, regulators may offer new regulations and legislation in the future to the Ministry of Finance and the Amman Stock Exchange.

Keywords: accounting expenditure; advertising expenditure; liquidity; small and medium enterprises (SMEs)

Research Title: The sustainable alleviation of poverty and the promotion of green development in Tibet

Author: Fahd Mohammed Saleh Al-Duais, Published Year: 2023

2023· Forum on the Development of Xizang (Tibet) (May 23, 2023), Beijing Conference Center (No.88 Laiguangying West Road, Chaoyang District, Beijing)

Faculty: Business

Abstract: This paper aims to examine the social development outcomes historically in Tibet regarding poverty eradication, education, employment, health care, and social integration. In addition, the paper will provide concrete suggestions for improving future social development work in Tibet. The main theoretical approach used is a literature and policy review of social development in Tibet. Tibet's social development strategy has been reviewed. Once Tibet's basic needs have been met, the road to progress is likely to be towards a more participatory approach, in which Tibetans will be able to contribute directly and influence their own future. This paper aims to provide a view of definitive account of recent historical development strategies and outcomes in Tibet; and, subsequently, the future prospects and challenges the region faces. It suggests increasing attention to vocational education and promoting and encouraging the maintenance of a sustainable environment, mitigating population growth, and integrating with other communities in other nearby counties and cities. Especially these factors lead in one way or another to the sustainability of poverty alleviation, development and the green environment.

Keywords: poverty alleviation, Tibet, China, Green Development, Sustainability

Research Title: Unravelling the intertwined nexus of firm performance, ESG practices, and capital cost in the Chinese business landscape

Author: Fahd Mohammed Saleh Al-Duais, Published Year: 2023

Faculty: Business

Abstract: This research explores the relationship between a company’s commitment to Environmental, Social, and Governance (ESG) factors and its capital equity cost (COE) in the Chinese market. Using statistical methods like regression analysis, the study aims to uncover how ESG disclosure relates to COE. Key findings reveal that environmental and social disclosures increase capital equity costs, indicating higher costs for companies with strong ESG practices. However, governance disclosures don’t significantly impact COE, suggesting that environmental and social aspects carry more weight in shaping investor perceptions and influencing costs compared to governance. The research also shows that this ESG-COE link is more significant for financially sound companies, indicating greater cost implications for strong performers. The study further demonstrates that strong ESG practices are perceived as lower risk, leading to lower capital equity costs. Chinese firms with high ESG scores tend to have lower capital costs, indicating rising investor appreciation for ESG in the Chinese market. The study’s robustness check supports these findings, reinforcing the growing importance of ESG in investment decisions. This research has implications for companies, investors, and policymakers, stressing the role of ESG in attracting investment and reducing costs. Policymakers can use these insights to encourage improved ESG practices and transparency. Overall, the study underscores ESG’s impact on capital equity costs in China, offering valuable insights for decision-makers and highlighting ESG’s relevance in financial choices.

Keywords: ESG rating score, cost of capital, firm performance, investment decisions, transparency

Research Title: Development and Characterization of Gel-Based Buccoadhesive Bilayer Formulation of Nifedipine

Author: Mohammad Bayan, Published Year: 2023

Gels, 9

Faculty: Pharmacy

Abstract: A promising controlled drug delivery system has been developed based on polymeric buccoadhesive bilayered formulation that uses a drug-free backing layer and a polymeric hydrophilic gel buccoadhesive core layer containing nifedipine. The DSC thermogravimetric analysis confirms the drug’s entrapment in the gel layer and reveals no evidence of a potential interaction. Various ratios of bioadhesive polymers, including HPMC K100, PVP K30, SCMC, and CP 934, were combined with EC as an impermeable backing layer to ensure unidirectional drug release towards the buccal mucosa. The polymeric compositions of hydrophilic gel-natured HPMC, SCMC, and CP formed a matrix layer by surrounding the core nifedipine during compression. Preformulation studies were performed for all of the ingredients in order to evaluate their physical and flow characteristics. Ex vivo buccoadhesive strength, surface pH, swelling index, in vitro and in vivo drug release, and ex vivo permeation investigations were performed to evaluate the produced gel-based system. Rapid temperature variations had no appreciable impact on the substance’s physical properties, pharmacological content, or buccoadhesive strength during stability testing using actual human saliva. It was clear from a histological examination of the ex vivo mucosa that the developed system did not cause any irritation or inflammation at the site of administration. The formulation NT5 was the best one, with a correlation coefficient of 0.9966. The in vitro and in vivo drug release profiles were well correlated, and they mimic the in vitro drug release pattern via the biological membrane. Thus, the developed gel-based formulation was found to be novel, stable, and useful for the targeted delivery of nifedipine.

Keywords: nifedipine; buccoadhesive; triggered delivery; ex vivo permeation; polymeric gel

Research Title: Household Food Insecurity and Nutritional Status of PreSchool Children Following Relaxation of COVID-19 Restrictions

Author: Yousef Abdel-Kareem Abusamra, Published Year: 2023

Journal of Xi’an Shiyou University, Natural Science Edition, VOLUME 19 ISSUE 06

Faculty: Pharmacy

Abstract: Studies found a high prevalence of household food insecurity (HFIS) and malnutrition and an association between them during the movement restriction period of the COVID-19 pandemic. This nutritional status should have improved by now as movement restrictions, including quarantine, have been lifted. Therefore, the goal of this cross-sectional study was to determine the current prevalence of HFIS and malnutrition and their associations and contributing factors among pre-school children (i.e., children under the age of 5 years) following relaxation of the COVID-19 restrictions in Jordan. A sample of 386 children (197 boys and 189 girls) in Irbid, Jordan, were recruited in this study following the simple random sampling method. The levels of HFIS and malnutrition were assessed using the Food Insecurity Experience Scale (FIES) and the World Health Organization (WHO) growth reference values, respectively. Relevant information were managed and measurements made and employed to calculate four major anthropometric indicators for the sample children (weight to height (WHZ), height to age (HAZ), weight to age (WAZ) and Body Mass Index to age (BMI/A) (BMI/A)). The results of analysis pointed out that prevalence of food insecurity among the sample children was 58.2%, where 19.9% of the kids were experiencing moderate food insecurity and 38.3% were suffering from severe food insecurity. On the other hand, prevalence of malnutrition among those children was 1.81%, where 1.55% of the kids were emaciated and 1.26% were severely emaciated. The results also indicated that mother’s age, number of children in the family, income of the family, monthly expenses on food and beverages and the energy expenses contributed significantly (p<0.05) to food insecurity. Moreover, the study found that HFIS had negative correlations with WHZ (r=−0.272, p=0.000), WAZ (r=−0.193, p=0.000) and BMI/A (r=−0.263, p=0.000) and a positive correlation with HAZ(r=0.041, p=0.00). The study reports high prevalence of HFIS among children under the age of 5 years in Jordan, even after relaxation of the COVID-19 restrictions on mobility. However, prevalence of malnutrition among this group of the population is low. These results spotlight the continued impact of the COVID- 19 crisis on the financial statuses of households

Keywords: Anthropometry, Household Food Insecurity, Jordan, Malnutrition, Pre-school children.

Research Title: Corrosion inhibition of aluminum in HBr solutions by nonionic surfactants at different temperatures

Author: Adnan Dahadha, Published Year: 2023

International Journal of Corrosion and Scale Inhibition, 12

Faculty: Science

Abstract: The influence of nonionic surfactant micelles such as Tween 80, polyethylene glycol 400, and coco glucoside on the inhibition of aluminum corrosion in hydrobromic acid solutions was investigated via weight reduction, thermometric, and electrical conductivity techniques. In the absence of inhibitors, the rise in temperature and acid levels has led to a tremendous acceleration in the aluminum corrosion in HBr solutions. Intriguingly, coco glucoside, PEG 400, and Tween 80 have shown a remarkable inhibitory action on the corrosion of aluminum in the corrosive solutions at different temperatures. The findings demonstrated that the inhibition efficacy of inhibitors and the extent of surface coverage of the micelles on aluminum rise with higher concentration of the inhibitor and decline with rising temperature. Notably, Tween 80 was a more effective inhibitor than PEG 400, and coco glucoside at all temperatures. This effect may be explained by the force and type of their micelles’ adsorption on the aluminum surface, which occurs when hydrophilic regions of coherent layers of micelles donate their electrons to the metal surface. Also, the thermodynamic factors (ΔH0, ΔS0, and Ea) for the corrosion and adsorption processes were assessed and addressed. The experimental data were best fit by models of

Keywords: corrosion inhibitor, aluminum, nonionic surfactants, micelles, adsorption isotherms.

Research Title: Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

Author: Mohammad Bayan, Published Year: 2023

Antibiotics, 12

Faculty: Pharmacy

Abstract: The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, among others, for the present review. Along with these, marketed products, patents, and Clinicaltrials.gov were also referred to for our review. Different microbes such as bacteria, fungi, etc., and their diverse species and strains have been reviewed and found to be sensitive to metal-carrying formulations. The products are observed to restrict growth, multiplication, and biofilm formation effectively and adequately. Silver has an apt use in this area of treatment and recovery, and other metals like copper, gold, iron, and gallium have also been observed to generate antimicrobial activity. The present review identified membrane disruption, oxidative stress, and interaction with proteins and enzymes to be the primary microbicidal processes. Elaborating the action, nanoparticles and nanosystems are shown to work in our favor in well excelled and rational ways.

Keywords: metals; nanoparticles; antimicrobial action; microbicidal; biofilm formation inhibitors

Research Title: Le soutien logistique fourni par les femmes aux djihadistes, « Filles du djihad » exemple.

Author: Mohammad Al-Ghazu, Published Year: 2022

Dirasat, Human and Social Sciences مجلة دراسات : العلوم الانسانية والاجتماعية, 45/5

Faculty: Arts

Abstract: Cet article vise à éclaircir la participation des femmes au jihad avec les organisations islamiques djihadistes soit comme des épouses, soit comme solidaires à ces djihadistes. Il se divise ne trois partis principaux : Au premier, nous avons discuté des raisons qui les ont poussées au jihad. Dans le deuxième, nous avons souligné les moyens de recrutement et la catégorie des femmes visées. Quant au troisième, nous avons discuté de leur rôle dans ce jihad et les conditions de vie qu’elles subissaient lors de leur existence en Moyen Orient. En fait, elles ont offert leur soutien logistique souhaite aux djihadistes de Daesh, mais elles ont découvert tard qu’elles étaient trompées par l’image de ces personnes. Logistical support provided by women to jihadists. “Girls of Jihad” example. This research aims to clarify the participation of women in jihad with Islamic jihadist organizations either as wives or as solidarity with these jihadists. The research is divided into three parts: first, we discussed the reasons that pushed them to jihad. Second, we underlined the means of recruitment and the category of women targeted. Third, we discussed their role in jihad and the living conditions they endured during their existence in the Middle East. In fact, they offered their logistical support to the jihadists of ISIS, but discovered that they were deceived by the image of these people.

Keywords: soutien logistique, jihad, femmes djihadistes, islam, Daesh.