351 |
Research Title: Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole
Author: Soha Telfah, Published Year: 2020
Current Drug Metabolism, 1
Faculty: Pharmacy
Abstract: Recently, a series of 15 compounds with 2,4,5-trisubstitutedthiazole scaffold having
Keywords: Cytotoxicity, 2-amino-5-aryl-thiazole, breast cancer cell lines
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352 |
Research Title: Synthesis and evaluation of 2,4,5-trisubstitutedthiazoles as carbonic anhydrase-III inhibitors
Author: Soha Telfah, Published Year: 2020
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35
Faculty: Pharmacy
Abstract: A series of 17 compounds 12–16 b with 2,4,5 trisubstitutedthiazole scaffold having 5 aryl group, 4 carboxylic acid/ester moiety, and 2-amino/ amido /ureido functional groups were synthesized, characterized,
Keywords: Carbonic anhydrase III inhibitors; 2-amino-5-arylthiazole Hummel–Dreyer method of chromatography
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353 |
Research Title: Intertextuality in the Cordovan Maqama_ An Analytical Statistical study
Author: Omar Faris Yousif AlKafaween, Published Year: 2021
مجلة المشكاة للعلوم الإنسانية والاجتماعية, مقبول للنشر
Faculty: Arts
Abstract: The study aimed to shed light on an important mechanism for the construction of the text in the Cordovan Maqama, one of the Andalusian Maqamat in the 6th century AH, that is the mechanism of intertextuality. The study starts with introducing this Maqama and the context of its production besides a summary of its plot, and then the definition and importance of intertextuality are introduced before explaining the main intertextual forms that are found in this Maqama via a statistical process which highlights the role of intertextuality in constructing the Maqama text on both the aesthetic and the thematic aspects. The main forms of intertextuality in the Maqama are the religious intertextuality, especially the Quranic one, and the literary intertextuality, such as poetic and proverbial intertextuality, in addition to references to traditional figures. The research method used was the statistical one in combination with the descriptive and formalist methods. The study ends with several conclusions, the most important of which is that literary intertextuality, particularly poetry, is the most common in the Maqama, while the rest of the forms are present almost equally, and the style of intertextuality in most of them takes the form of direct quotation.
Keywords: Intertextuality, Intertextuality Forms, Cordovan Maqama
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354 |
Research Title: Phytochemical and Biological Investigation of Aristolochia maurorum L
Author: Soha Telfah, Published Year: 2006
Verlag der Zeitschrift für Naturforschung, 61
Faculty: Pharmacy
Abstract: Aristolochia maurorum L. of Jordanian origin has been investigated phytochemically, quantitatively, and biologically. Three atypical alkaloids, namely aristolochic acid I (1), aristolochic acid II (2) and aristolochic acid IIIa (3), have been isolated and identified. Of these known 1-phenanthrenecarboxylic acids, 2 and 3 are reported for the first time from this species. The identified compounds 1-3 were first evaluated biologically as cytotoxic agents against the brine shrimp lethality test (BST), in which compound 1 was found to be the most potent (LC50, 4.9 microg/mL). The antiplatelet activity of the methanolic extracts, the acidic fractions of aerial and root parts, and the identified compounds 1-3 were evaluated using an automatic platelet aggregometer and coagulation tracer (APACT 2). Using external reference standards, and a reverse-phase isocratic method, the distribution of aristolochic acid I and aristolochic acid II in different plant parts of Aristolochia maurorum L. during flowering stage was analyzed by PDA-HPLC. A quantitative comparison between two previously reported extraction methods was also made. Roots were found to be the main storage of aristolochic acid I and aristolochic acid II during flowering stage with about 0.22 and 0.108% (w/w), respectively.
Keywords: Aristolochic Acids, Aristolochia maurorum, Antiplatelet Activity
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355 |
Research Title: A Holystic Self-adaptive systems model
Author: Said Ahmad Ammar Ghoul, Published Year: 2021
, International Journal of Software Engineering & Applications (IJSEA), , 12, 2/3, May 2021
Faculty: Information Technology
Abstract: The recent self-adaptive software systematic literature reviews stated clearly the following insufficiencies: (1) the need for a holistic self-adaptive software model to integrate its different aspects (2) The limitation of adaptations to context changes (3) The absence of a general and complete adaptations’ picture allowing its understandability, maintainability, evaluation, reuse, and variability. (4) The need for an explicit and a detailed link with resources, and (5) a usual limitation to known events.
In order to metigate these insufficiencies, this paper is proposing a holistic model that integrates the operating, adaptations, and adaptations’ manager aspects. The proposed model covers all possible adaptations: operating (dealing with software functions failures), lifecycle (handling adaptations required by some software lifecycle steps), and context (facing context changes events). The presented work introduces the concept of software adaptations process integrating the specifications of all the above kind of adaptations. In fact, this work shows an explicit trace to its pure bio-inspired origin.
An application of the proposed approach on a “car industry case study” demonstrated its feasibility in comparison with similar works that proved its meaningful added value and its promising research perspectives.
Keywords: Self-adaptive software, bio-inspired approach, adaptation events, immune system.
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Research Title: A Feature Model Based Configuration Reuse for Context-aware Systems
Author: Said Ahmad Ammar Ghoul, Published Year: 2021
Computers, Materials & Continua (Scopus, Q2), Under press
Faculty: Information Technology
Abstract: Most of Self-Adaptive Systems (SAS) use Feature Models (FMs) to represent their complex architecture and benefit from reusing commonalities and variability information. However triggering SAS reconfiguration process, each time a system needs to be adapted, continues to cost time and effort. Current FM techniques have modelled SAS concepts, focusing on representing and reusing elementary features without taking into consideration modelling and reusing configurations. This work presents an extension to the FM in order to remedy this important problem by introducing and managing the configuration feature. Evaluation shows that the reuse of configuration feature reduces reconfiguration process effort and time during the run time in order to meet the required scenario according to the context.
Keywords: Self-Adaptive system, Feature Model, System reuse, Configuration management, Variability modelling
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357 |
Research Title: Investigating the efficiency of financial markets: Empirical evidence from MENA countries
Author: Izzeddien Naef Ananzeh, Published Year: 2021
Investment management and financial innovations, Volume 18, Issue 1,
Faculty: Business
Abstract: The market efficiency hypothesis has become an important concept for all investors
looking to own internationally diversified portfolios, which coincides with an increase
in investment flows between all countries, both developed and undeveloped. This
study was aimed at investigating the efficiency of a group of Arab stock markets located
in the Middle East and North Africa (MENA) region according to the Random Walk
Hypotheses (RWH) at weak form. The study covered the markets of Jordan, Egypt,
Saudi Arabia, UAE, Bahrain, and Oman.
The empirical results of all tests used in this study rejected the RWH at a weak form for
all markets through all tests applied – Unit root test, Variance Ratio Test, and Run Test.
The result of this study contradicts the results of many studies conducted on developed
and emerging markets. This can be a good indication of the ineffectiveness of the reforms that have been adopted by responsible bodies on these markets.
Based on this result, all efforts made to expand and deepen these markets should be intensified by improving liquidity, transparency, enhancing investment culture in these
countries; supporting legislative and regulatory reforms to attract investment, and developing the financial sector in these markets as a whole.
Keywords: MENA markets, market efficiency, financial markets, unit root tests, run test, variance ratio test
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358 |
Research Title: Expanding the phenotypic spectrum of FINCA (fibrosis, neurodegeneration, and cerebral angiomatosis) syndrome beyond infancy
Author: Tawfiq Froukh, Published Year: 2021
Clinical genetics, 100
Faculty: Science
Abstract: Fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA, MIM#618278) is a
rare clinical condition caused by bi-allelic variants in NHL repeat containing protein 2
(NHLRC2, MIM*618277). Pulmonary disease may be the presenting sign and the few
patients reported so far, all deceased in early infancy. Exome sequencing was performed
on patients with childhood interstitial lung disease (chILD) and additional neurological
features. The chILD-EU register database and an in-house database were
searched for patients with NHLRC2 variants and clinical features overlapping FINCA
syndrome. Six patients from three families were identified with bi-allelic variants in
NHLRC2. Two of these children died before the age of two while four others survived
until childhood. Interstitial lung disease was pronounced in almost all patients during
infancy and stabilized over the course of the disease with neurodevelopmental delay
(NDD) evolving as the key clinical finding. We expand the phenotype of FINCA syndrome to a multisystem disorder with variable severity. FINCA syndrome should
also be considered in patients beyond infancy with NDD and a history of distinct
interstitial lung disease. Managing patients in registers for rare diseases helps identifying
new diagnostic entities and advancing care for these patients.
Keywords: cerebropulmonary disease, childhood interstitial lung disease, cholesterol pneumonia, FINCA, lung fibrosis, lipoid pneumonitis, multi-organ disease, NHLRC2
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359 |
Research Title: Comparative effect of valsartan versus valsartan-hydrochlorthiazide on the serum lipid profile in hypertensive patients
Author: Najlaa Saadi Ismael, Published Year: 2021
Current Topics in Pharmacology, 25
Faculty: Allied Medical Sciences
Abstract: The objective of this study is to investigate the impact of valsartan versus valsartan-hydrochlorothiazide on the lipid profile parameters in hypertensive patients in comparison with control. Healthy control. Healthy control and hypertensive patients of either sex participated in this study; they were assigned into three groups (of twenty-three subjects each). Group 1 was the control group. Group 2 comprised of hypertensive patients treated with valsartan and Group 3 comprised of hypertensive patients treated with valsartan-hydrochlorothiazide (valsartan-HCT) combination once a day with a dose of 80 mg or 160 mg and 80/12.5 mg or 160/12.5 mg or 160/25 mg (the duration was not less than 3 months), respectively. Blood samples were collected from each subject and then the parameters of the lipid profile were measured in both control and hypertensive patients using a biochemical analysis. Systolic and diastolic blood pressure in patients treated with valsartan and valsartan-HCT drugs were significantly higher than that of the control group. In treated groups, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) were significantly higher than those of the control group. However, in the valsartan-HCT group, high-density lipoprotein cholesterol (HDL-C) was significantly lower than that of the control group, while in the valsartan group, high-density lipoprotein cholesterol (HDL-C) was non-significantly lower than that of the control group. This study confirmed that the treatment with valsartan and valsartan-HCT may not control the blood Pressure and that the drugs may interfere with lipid profile. Hence, a readjustment of the therapy is important.
Keywords: hypertensive patients, valsartan, hydrochlorthiazide, lipid profile
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Research Title: القواعد الأخلاقية في المعاملات المالية الإسلامية
Author: Ahmed Mohammed Al-Jayousi, Published Year: 2021
المحلة العالمية للتسويق الاسلامي , المجلد 10 ، العدد 3
Faculty: Business
Abstract: تعتبر الأخلاق والقيم أصلاً من الأصول التي قامت عليها الشريعة الإسلامية، وأوجبت على كل أتباعها (سواء كانوا أشخاصاً طبيعيين أم اعتباريين) الالتزام بها. كما أعلت شأنها، ورفعت مكانتها، حتى وضعتها في قمة الأولويات التي تحكم المعاملات بين الأفراد الجماعات. ولم يقتصر الأمر على الشريعة الإسلامية، بل إنها كانت محط اهتمام معظم الشرائع السماوية، والأنظمة الوضعية، فجميعها دعت إلى التحلي بمكارم الأخلاق، ووجهت أتباعها للتقيد بها، والاستقامة عليها، لما لها من آثار في ترسيخ السلوكيات النبيلة، من العدل والنزاهة، والتعاون والإيثار، والصدق والإخلاص، والأمانة والوفاء، واستئصال السلوكيات الذميمة وغير السوية من حياة الفرد والمجتمع، فتسلم المعاملات وتستقر العلاقات.
ومن ناحية أخرى فإن التمويل الإسلامي مرتبط (بحكم طبيعته) بمنظومة من الأخلاق والقيم، بل إن معظم أساليب التمويل والاستثمار في البنوك والمؤسسات المالية الإسلامية (بدءاً من المضاربة والمشاركة وانتهاءً بالسلم والاستصناع) تقوم أساساً على مدى التزام العميل بالقواعد الأخلاقية المتمثلة بالصدق والأمانة والوفاء بالعقود ... وغيرها. ولعل ذلك يفسر سبب تركز تمويلات المصارف الإسلامية على بيوع المرابحة للآمر بالشراء، والابتعاد عن صيغ المضاربة والمشاركة نظراً للمخاطر الأخلاقية فيهما.
ومن هنا جاءت فكرة هذه الورقة البحثية بهدف تسليط الضوء على القواعد الأخلاقية للمعاملات المالية في الإسلام، ومكانتها وخصائصها، وبالأخص تلك المرتبطة بمنظمات الأعمال ومنها البنوك والمؤسسات المالية الإسلامية، والآثار السلبية لعدم الالتزام بها من قبل الأفراد والمنظمات.
Keywords: الأخلاق والقيم، التمويل الإسلامي، معاملات مالية، أخلاقيات الأعمال.
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