Research Title: Anticancer Activity and In Silico ADMET Properties of 2,4,5-Trisubstitutedthiazole

Author: Soha Telfah, Published Year: 2020

Current Drug Metabolism, 1

Faculty: Pharmacy

Abstract: Recently, a series of 15 compounds with 2,4,5-trisubstitutedthiazole scaffold having

Keywords: Cytotoxicity, 2-amino-5-aryl-thiazole, breast cancer cell lines

Research Title: Synthesis and evaluation of 2,4,5-trisubstitutedthiazoles as carbonic anhydrase-III inhibitors

Author: Soha Telfah, Published Year: 2020

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 35

Faculty: Pharmacy

Abstract: A series of 17 compounds 12–16 b with 2,4,5 trisubstitutedthiazole scaffold having 5 aryl group, 4 carboxylic acid/ester moiety, and 2-amino/ amido /ureido functional groups were synthesized, characterized,

Keywords: Carbonic anhydrase III inhibitors; 2-amino-5-arylthiazole Hummel–Dreyer method of chromatography

Research Title: Intertextuality in the Cordovan Maqama_ An Analytical Statistical study

Author: Omar Faris Yousif AlKafaween, Published Year: 2021

مجلة المشكاة للعلوم الإنسانية والاجتماعية, مقبول للنشر

Faculty: Arts

Abstract: The study aimed to shed light on an important mechanism for the construction of the text in the Cordovan Maqama, one of the Andalusian Maqamat in the 6th century AH, that is the mechanism of intertextuality. The study starts with introducing this Maqama and the context of its production besides a summary of its plot, and then the definition and importance of intertextuality are introduced before explaining the main intertextual forms that are found in this Maqama via a statistical process which highlights the role of intertextuality in constructing the Maqama text on both the aesthetic and the thematic aspects. The main forms of intertextuality in the Maqama are the religious intertextuality, especially the Quranic one, and the literary intertextuality, such as poetic and proverbial intertextuality, in addition to references to traditional figures. The research method used was the statistical one in combination with the descriptive and formalist methods. The study ends with several conclusions, the most important of which is that literary intertextuality, particularly poetry, is the most common in the Maqama, while the rest of the forms are present almost equally, and the style of intertextuality in most of them takes the form of direct quotation.

Keywords: Intertextuality, Intertextuality Forms, Cordovan Maqama

Research Title: Phytochemical and Biological Investigation of Aristolochia maurorum L

Author: Soha Telfah, Published Year: 2006

Verlag der Zeitschrift für Naturforschung, 61

Faculty: Pharmacy

Abstract: Aristolochia maurorum L. of Jordanian origin has been investigated phytochemically, quantitatively, and biologically. Three atypical alkaloids, namely aristolochic acid I (1), aristolochic acid II (2) and aristolochic acid IIIa (3), have been isolated and identified. Of these known 1-phenanthrenecarboxylic acids, 2 and 3 are reported for the first time from this species. The identified compounds 1-3 were first evaluated biologically as cytotoxic agents against the brine shrimp lethality test (BST), in which compound 1 was found to be the most potent (LC50, 4.9 microg/mL). The antiplatelet activity of the methanolic extracts, the acidic fractions of aerial and root parts, and the identified compounds 1-3 were evaluated using an automatic platelet aggregometer and coagulation tracer (APACT 2). Using external reference standards, and a reverse-phase isocratic method, the distribution of aristolochic acid I and aristolochic acid II in different plant parts of Aristolochia maurorum L. during flowering stage was analyzed by PDA-HPLC. A quantitative comparison between two previously reported extraction methods was also made. Roots were found to be the main storage of aristolochic acid I and aristolochic acid II during flowering stage with about 0.22 and 0.108% (w/w), respectively.

Keywords: Aristolochic Acids, Aristolochia maurorum, Antiplatelet Activity

Research Title: ‎A Holystic Self-adaptive systems model‎

Author: Said Ahmad Ammar Ghoul, Published Year: 2021

‎, International Journal of Software Engineering & Applications (IJSEA), , 12, 2/3, May 2021‎

Faculty: Information Technology

Abstract: The recent self-adaptive software systematic literature reviews stated clearly the following ‎insufficiencies: (1) the need for a holistic self-adaptive software model to integrate its different ‎aspects (2) The limitation of adaptations to context changes (3) The absence of a general and ‎complete adaptations’ picture allowing its understandability, maintainability, evaluation, reuse, and ‎variability. (4) The need for an explicit and a detailed link with resources, and (5) a usual limitation ‎to known events. ‎ In order to metigate these insufficiencies, this paper is proposing a holistic model that integrates the ‎operating, adaptations, and adaptations’ manager aspects. The proposed model covers all possible ‎adaptations: operating (dealing with software functions failures), lifecycle (handling adaptations ‎required by some software lifecycle steps), and context (facing context changes events). The ‎presented work introduces the concept of software adaptations process integrating the ‎specifications of all the above kind of adaptations. In fact, this work shows an explicit trace to its ‎pure bio-inspired origin. ‎ An application of the proposed approach on a “car industry case study” demonstrated its feasibility ‎in comparison with similar works that proved its meaningful added value and its promising research ‎perspectives.‎

Keywords: Self-adaptive software, bio-inspired approach, adaptation events, immune system.‎

Research Title: ‎A Feature Model Based Configuration Reuse for Context-aware Systems‎

Author: Said Ahmad Ammar Ghoul, Published Year: 2021

Computers, Materials & Continua (‎Scopus, Q2), Under press

Faculty: Information Technology

Abstract: Most of Self-Adaptive Systems (SAS) use Feature Models (FMs) to represent their complex ‎architecture and benefit from reusing commonalities and variability information. However ‎triggering SAS reconfiguration process, each time a system needs to be adapted, continues to ‎cost time and effort. Current FM techniques have modelled SAS concepts, focusing on ‎representing and reusing elementary features without taking into consideration modelling and ‎reusing configurations. This work presents an extension to the FM in order to remedy this ‎important problem by introducing and managing the configuration feature. Evaluation shows that ‎the reuse of configuration feature reduces reconfiguration process effort and time during the run ‎time in order to meet the required scenario according to the context.‎

Keywords: Self-Adaptive system, Feature Model, System reuse, Configuration management, Variability ‎modelling‎

Research Title: Investigating the efficiency of financial markets: Empirical evidence from MENA countries

Author: Izzeddien Naef Ananzeh, Published Year: 2021

Investment management and financial innovations, Volume 18, Issue 1,

Faculty: Business

Abstract: The market efficiency hypothesis has become an important concept for all investors looking to own internationally diversified portfolios, which coincides with an increase in investment flows between all countries, both developed and undeveloped. This study was aimed at investigating the efficiency of a group of Arab stock markets located in the Middle East and North Africa (MENA) region according to the Random Walk Hypotheses (RWH) at weak form. The study covered the markets of Jordan, Egypt, Saudi Arabia, UAE, Bahrain, and Oman. The empirical results of all tests used in this study rejected the RWH at a weak form for all markets through all tests applied – Unit root test, Variance Ratio Test, and Run Test. The result of this study contradicts the results of many studies conducted on developed and emerging markets. This can be a good indication of the ineffectiveness of the reforms that have been adopted by responsible bodies on these markets. Based on this result, all efforts made to expand and deepen these markets should be intensified by improving liquidity, transparency, enhancing investment culture in these countries; supporting legislative and regulatory reforms to attract investment, and developing the financial sector in these markets as a whole.

Keywords: MENA markets, market efficiency, financial markets, unit root tests, run test, variance ratio test

Research Title: Expanding the phenotypic spectrum of FINCA (fibrosis, neurodegeneration, and cerebral angiomatosis) syndrome beyond infancy

Author: Tawfiq Froukh, Published Year: 2021

Clinical genetics, 100

Faculty: Science

Abstract: Fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA, MIM#618278) is a rare clinical condition caused by bi-allelic variants in NHL repeat containing protein 2 (NHLRC2, MIM*618277). Pulmonary disease may be the presenting sign and the few patients reported so far, all deceased in early infancy. Exome sequencing was performed on patients with childhood interstitial lung disease (chILD) and additional neurological features. The chILD-EU register database and an in-house database were searched for patients with NHLRC2 variants and clinical features overlapping FINCA syndrome. Six patients from three families were identified with bi-allelic variants in NHLRC2. Two of these children died before the age of two while four others survived until childhood. Interstitial lung disease was pronounced in almost all patients during infancy and stabilized over the course of the disease with neurodevelopmental delay (NDD) evolving as the key clinical finding. We expand the phenotype of FINCA syndrome to a multisystem disorder with variable severity. FINCA syndrome should also be considered in patients beyond infancy with NDD and a history of distinct interstitial lung disease. Managing patients in registers for rare diseases helps identifying new diagnostic entities and advancing care for these patients.

Keywords: cerebropulmonary disease, childhood interstitial lung disease, cholesterol pneumonia, FINCA, lung fibrosis, lipoid pneumonitis, multi-organ disease, NHLRC2

Research Title: Comparative effect of valsartan versus valsartan-hydrochlorthiazide on the serum lipid profile in hypertensive patients

Author: Najlaa Saadi Ismael, Published Year: 2021

Current Topics in Pharmacology, 25

Faculty: Allied Medical Sciences

Abstract: The objective of this study is to investigate the impact of valsartan versus valsartan-hydrochlorothiazide on the lipid profile parameters in hypertensive patients in comparison with control. Healthy control. Healthy control and hypertensive patients of either sex participated in this study; they were assigned into three groups (of twenty-three subjects each). Group 1 was the control group. Group 2 comprised of hypertensive patients treated with valsartan and Group 3 comprised of hypertensive patients treated with valsartan-hydrochlorothiazide (valsartan-HCT) combination once a day with a dose of 80 mg or 160 mg and 80/12.5 mg or 160/12.5 mg or 160/25 mg (the duration was not less than 3 months), respectively. Blood samples were collected from each subject and then the parameters of the lipid profile were measured in both control and hypertensive patients using a biochemical analysis. Systolic and diastolic blood pressure in patients treated with valsartan and valsartan-HCT drugs were significantly higher than that of the control group. In treated groups, low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and total cholesterol (TC) were significantly higher than those of the control group. However, in the valsartan-HCT group, high-density lipoprotein cholesterol (HDL-C) was significantly lower than that of the control group, while in the valsartan group, high-density lipoprotein cholesterol (HDL-C) was non-significantly lower than that of the control group. This study confirmed that the treatment with valsartan and valsartan-HCT may not control the blood Pressure and that the drugs may interfere with lipid profile. Hence, a readjustment of the therapy is important.

Keywords: hypertensive patients, valsartan, hydrochlorthiazide, lipid profile

Research Title: القواعد الأخلاقية في المعاملات المالية الإسلامية

Author: Ahmed Mohammed Al-Jayousi, Published Year: 2021

المحلة العالمية للتسويق الاسلامي , المجلد 10 ، العدد 3

Faculty: Business

Abstract: تعتبر الأخلاق والقيم أصلاً من الأصول التي قامت عليها الشريعة الإسلامية، وأوجبت على كل أتباعها (سواء كانوا أشخاصاً طبيعيين أم اعتباريين) الالتزام بها. كما أعلت شأنها، ورفعت مكانتها، حتى وضعتها في قمة الأولويات التي تحكم المعاملات بين الأفراد الجماعات. ولم يقتصر الأمر على الشريعة الإسلامية، بل إنها كانت محط اهتمام معظم الشرائع السماوية، والأنظمة الوضعية، فجميعها دعت إلى التحلي بمكارم الأخلاق، ووجهت أتباعها للتقيد بها، والاستقامة عليها، لما لها من آثار في ترسيخ السلوكيات النبيلة، من العدل والنزاهة، والتعاون والإيثار، والصدق والإخلاص، والأمانة والوفاء، واستئصال السلوكيات الذميمة وغير السوية من حياة الفرد والمجتمع، فتسلم المعاملات وتستقر العلاقات. ومن ناحية أخرى فإن التمويل الإسلامي مرتبط (بحكم طبيعته) بمنظومة من الأخلاق والقيم، بل إن معظم أساليب التمويل والاستثمار في البنوك والمؤسسات المالية الإسلامية (بدءاً من المضاربة والمشاركة وانتهاءً بالسلم والاستصناع) تقوم أساساً على مدى التزام العميل بالقواعد الأخلاقية المتمثلة بالصدق والأمانة والوفاء بالعقود ... وغيرها. ولعل ذلك يفسر سبب تركز تمويلات المصارف الإسلامية على بيوع المرابحة للآمر بالشراء، والابتعاد عن صيغ المضاربة والمشاركة نظراً للمخاطر الأخلاقية فيهما. ومن هنا جاءت فكرة هذه الورقة البحثية بهدف تسليط الضوء على القواعد الأخلاقية للمعاملات المالية في الإسلام، ومكانتها وخصائصها، وبالأخص تلك المرتبطة بمنظمات الأعمال ومنها البنوك والمؤسسات المالية الإسلامية، والآثار السلبية لعدم الالتزام بها من قبل الأفراد والمنظمات.

Keywords: الأخلاق والقيم، التمويل الإسلامي، معاملات مالية، أخلاقيات الأعمال.